Pathophysiological Role of Pigment Epithelium-Derived Factor (PEDF) in Hepatic Disorders

Authors: Yamagishi, S.-I.; Matsui, T.; Kawaguchi, T.; Sata, M.

Source: Current Medicinal Chemistry, Volume 17, Number 19, July 2010 , pp. 1995-2000(6)

Publisher: Bentham Science Publishers

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Abstract:

Pigment epithelium-derived factor (PEDF) is a glycoprotein that belongs to the superfamily of serine protease inhibitors with a potent neuronal differentiating activity. Recently, PEDF is found to be a highly effective inhibitor of pathological angiogenesis in both cell culture and animal models. Further, it has also been shown to have neuroprotective, anti-oxidative and anti-inflammatory properties, any of which could potentially be exploited as a therapeutic option for the treatment of cardiometabolic disorders, neurodegenerative disease and cancers. However, as far as we know, there are few comprehensive reviews to deal with the involvement of PEDF in hepatic disease. This article summarizes the pathophysiological role of PEDF for various liver diseases such as hepatic insulin resistance, alcoholic and nonalcoholic liver disease, and hepatocellular carcinoma, and its potential therapeutic implication in these devastating disorders.

Keywords: hepatic insulin resistance; oxidative stress; hepatocellular carcinoma; PEDF

Document Type: Research article

Publication date: 2010-07-01

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Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.