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Interaction of Nerve Agent Antidotes with Cholinergic Systems

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Abstract:

The poisoning with organophosphorus compounds represents a life threatening danger especially in the time of terroristic menace. No universal antidote has been developed yet and other therapeutic approaches not related to reactivation of acetylcholinesterase are being investigated. This review describes the main features of the cholinergic system, cholinergic receptors, cholinesterases and their inhibitors. It also focuses on the organophosphorus nerve agents, their properties, effects and a large part describes various possibilities in treatments, mainly traditional oxime therapies based on reactivation of AChE. Furthermore, non-cholinesterase coupled antidotal effects of the oximes are thoroughly discussed. These antidotal effects principally include oxime interactions with muscarinic and nicotinic receptors.

Keywords: Acetylcholinesterase; antidotes; cholinergic system; muscarinic receptors; nerve agents; nicotinic receptors; ogranophosphates

Document Type: Research Article

DOI: http://dx.doi.org/10.2174/092986710791111260

Affiliations: Department of Toxicology, Faculty of Military Health Science, University of Defense Trebesska 1575, 500 01 Hradec Kralove, Czech Republic.

Publication date: June 1, 2010

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  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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