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New and Bioactive Natural Products Isolated from Madagascar Plants and Marine Organisms

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Abstract:

Madagascar, the world's fourth biggest island has a unique biodiversity. The interest on the phytochemical investigation of Malagasy plant and marine natural products started from the isolation of the potent anti-cancerous bisindole alkaloids: vinblastine and vincristine. In this paper, work published in the last two decades (1991-2009) on 262 new natural products isolated from Malagasy higher plants, liverworts and marine organisms is reviewed. Several results on the bioassays of the isolated new natural products have been reported.

Keywords: Madagascar; bioactivities; biodiversity; marine organisms; natural products; plants

Document Type: Research Article

DOI: http://dx.doi.org/10.2174/092986710790827834

Affiliations: Department of Chemistry, M/C 0212, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061-0212, USA.

Publication date: April 1, 2010

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  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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