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Recent Advances on Platensimycin: A Potential Antimicrobial Agent

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Abstract:

Platensimycin, an active metabolite of Streptomyces platensis, was initially discovered by a combination of RNA interferin induced gene-silencing and library screening to microbial extracts. Platensimycin selectively inhibits β- ketoacyl-acyl carrier protein (ACP) synthase II (FabF) that is recognized as an effective broad-spectrum antibiotic against drug-resistant microorganism strains. Its novel scaffold and extraordinary antibacterial activity have drawn great attentions in recent years. So far, a number of synthetic strategies have been explored for the total synthesis of platensimycin. Moreover, many analogues have been investigated in terms of structure-activity relationships (SAR). This review provides a detailed overview of updated studies on platensimycin, focusing on various total and formal synthetic strategies, development of analogues, and the structure-activity relationships.

Keywords: FabF; Platensimycin; SAR; analogues; antibiotic; discovery; platencin; total synthetic strategies

Document Type: Research Article

DOI: https://doi.org/10.2174/092986710790827852

Affiliations: Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing210009, China.

Publication date: 2010-04-01

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