An Overview on Different Classes of Viral Entry and Respiratory Syncitial Virus (RSV) Fusion Inhibitors

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Abstract:

The therapeutic approach to AIDS is based on the combination of different drugs in the highly active antiretroviral therapy (HAART) regimen. These drugs have a wide variety of side effects, and some strains of HIV can develop resistance: for these reasons new anti-HIV drugs are needed.

In the wide field of anti-HIV medicine this review covers different classes of drugs which inhibit viral entry: in particular the classification of main categories, their mode of action and some new candidates for AIDS therapy are contemplated.

Also covered in this review are respiratory syncytial virus (RSV) fusion inhibitors.

Keywords: Aids; CCR5; CD4 receptor; CXCR4; HIV fusion inhibitors; RSV fusion inhibitors; coreceptor; viral entry inhibitors

Document Type: Research Article

DOI: http://dx.doi.org/10.2174/092986710790820561

Affiliations: Dipartimento Farmaco Chimico Tossicologico, Facolta di Farmacia, via F. Muroni 23/A, 07100 Sassari, Italy.

Publication date: April 1, 2010

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  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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