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Targeting Tumor Lymphangiogenesis: An Update

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Abstract:

Various human tumors preferentially metastasize by lymphatic route and lymphovascular invasion predicts lymph node metastasis. In this review article, we will summarize recent literature data concerning lymphangiogenesis, focusing on tumor lymphangiogenesis. In detail, we try to answer some important questions related to: a) The specificity of lymphatic endothelial cell markers; b) The differential characteristics of lymphatic vessels in tumors; c) The interplay between different lymphangiogenic factors; d) The role of pre-existing and newly-formed lymphatic vessels in tumors and their proliferative potential; e) The role of lymphatic vessels in tumor metastases; e) The prognostic significance of lymphatic microvascular density in tumors; f) The inhibition of lymphangiogenesis in tumors.

Keywords: Lymphangiogenesis; lymphatic endothelial cell; lymphatic microvascular density; metastases; tumor progression; vascular endothelial growth factor

Document Type: Research Article

DOI: http://dx.doi.org/10.2174/092986710790514471

Affiliations: Department of Human Anatomy and Histology, University of Bari Medical School, Piazza G. Cesare, 11, Policlinico, 70124 Bari, Italy.

Publication date: March 1, 2010

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  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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