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Specific Recognition of DNA by Small Molecules

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Abstract:

DNA exhibits many attractive features in the development of drug design and disease treatment, and there are some successful events for drugs targeting to DNA in clinic use. Nowadays, the specific recognition of DNA by small molecules is the crucial factor of the sustainable development of DNA-target drugs, for the serious side-effects of existing drugs. In this review, we discussed the current efforts of DNA-drug specific interaction that concerned with various DNA recognition models, such as abasic, mismatch or bulge site recognition, specific sequence recognition, and secondary structure recognition. Some compounds are found to show remarkable potential to be ideal drug.

Keywords: DNA specific recognition; interaction; small molecules

Document Type: Research Article

DOI: http://dx.doi.org/10.2174/092986710790112648

Affiliations: College of Chemical and Molecular Sciences, Wuhan University, Hubei, Wuhan 430072, P. R. of China.

Publication date: January 1, 2010

More about this publication?
  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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