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A Review on Biomedical Applications of Single-Walled Carbon Nanotubes

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Abstract:

Single-walled carbon nanotubes (SWNTs), a member of the carbon family, are the one-dimensional analogues of zero-dimensional fullerene molecules with unique structural and electronic properties. Since the discovery of SWNTs, they have been extensively studied for biomedical applications. In biological media SWNTs have unique near-infrared intrinsic fluorescence, inherent Raman spectroscopy and photoacoustic signal associated with the graphene in SWNTs which makes them ideal for noninvasive and high sensitivity detection. SWNTs have been broadly investigated as imaging agents for the evaluation of tumor targeting and localization of SWNTs in vitro and in vivo. Rational functionalization can also endow SWNTs with desired properties for biomedical applications. Functionalized SWNTs with significantly reduced toxicity have been employed as carriers to deliver various anticancer drugs, proteins and nucleic acids to the diseased tissues specifically and maximize the bioavailability of the drugs by improving solubility and increasing circulation time. This manuscript will highlight the recent employment of SWNTs in the field of nanomedicine and bioimaging, and also outline the challenges and future opportunities for biomedical applications of SWNTs.

Keywords: CNTs dispersion; Carbon nanotubes; biocompatibility; drug delivery; molecular imaging

Document Type: Research Article

DOI: https://doi.org/10.2174/092986710789957742

Affiliations: College of Chemistry & Molecular Sciences, Wuhan University, Wuhan 430072, P. R. China.

Publication date: 2010-01-01

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  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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