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Syntheses, Transformations and Pharmaceutical Applications of Kynurenic Acid Derivatives

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The syntheses and transformations of 4-hydroxyquinoline-2-carboxylic acid, kynurenic acid, are reviewed, and special attention is paid to the pharmacological activities and pharmaceutical applications of its derivatives.

Keywords: Kynurenic acid; diabetes mellitus; hypertension; kynurenic acid derivatives; neurological disorders; retinal damage; schizophrenia

Document Type: Research Article


Affiliations: Institute of Pharmaceutical Chemistry and Research Group for Stereochemistry, Hungarian Academy of Sciences, University of Szeged, H-6720 Szeged, Eotvos u. 6, Hungary.

Publication date: 2009-12-01

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