The Yin and Yang of CD4+ Regulatory T Cells in Autoimmunity and Cancer
Abstract:The immune system balances effector responses with tolerance, to protect the host from pathogens while minimizing local damage to tissue. An altered control of immune homeostasis can lead to loss of tolerance to self antigens in autoimmunity, or promote unwanted tolerance to tumor growth. This review focuses on the dual activity of CD4+ regulatory T cells (Tregs) in autoimmunity and cancer. Tregs play a key role in the mechanisms of immune tolerance and actively suppress pro-inflammatory responses, thus providing a beneficial action in autoimmunity and detrimental effects in cancer.
Document Type: Research Article
Affiliations: Department of Medicine at the University of California Los Angeles, 1000 Veteran Avenue 32-59, Los Angeles, California 90095-1670.
Publication date: December 1, 2009
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