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Plant Polyphenols and Tumors: From Mechanisms to Therapies, Prevention, and Protection Against Toxicity of Anti-Cancer Treatments

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Abstract:

Polyphenolic molecules produced by higher plants in response to biotic and abiotic stresses exert numerous effects on tumorigenic cell transformation, and on tumor cells in vitro and in vivo, and may interact with conventional antitumor therapies. In the present review, we collected and critically discussed data on: (i) redox-dependent and redoxindependent mechanisms underlying cytotoxic/cytostatic effects of PPs and their metabolites towards tumor cells and cytoprotection of normal cells; (ii) mechanisms of anti-angiogenic and anti-metastatic action of PPs; (iii) PPs-associated phototoxicity against tumor cells and photoprotection of non-tumor cells; (iv) PPs effects on drug-metabolizing enzymes as a basis for their synergism or antagonism with chemotherapy; (v) molecular pathways leading to tumor chemoprevention by PPs; and (vi) PPs as protectors against toxic effects of chemo-, radio-, and photodynamic therapies.

Keywords: Plant polyphenols; chemoprevention; chemotherapy; cytoprotection; cytotoxicity; photoprotection; phototoxicity; tumors

Document Type: Research Article

DOI: http://dx.doi.org/10.2174/092986709789352312

Affiliations: Laboratory of Tissue Engineering & Skin Pathophysiology, Istituto Dermopatico dell'Immacolata (IDI IRCCS), Via Monti di Creta 104, Rome 00167, Italy.

Publication date: October 1, 2009

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  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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