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The Effects of Insulin and Insulin-Like Growth Factors on Tumor Vascularization: New Insights of Insulin-Like Growth Factor Family in Cancer

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Abstract:

It is currently believed that the development of a clinically relevant tumor needs new vessel formation provided by both angiogenesis (primary involving endothelial cells) and postnatal vasculogenesis (primary involving bone marrowderived cells). Clearly, it is important to identify factors that help to enhance the growth and “health” of tumors, as well as their further vascularization. The Insulin and Insulin-like Growth Factors (IGFs) systems play a key role in cellular metabolism, differentiation, proliferation, transformation and apoptosis, during normal and malignant growth. Moreover, these molecules seem essential in promoting tumor vascularization. Due to the complexity of these systems, the review has been focused on the role of insulin and IGFs signaling in the regulation of tumor angiogenesis and postnatal vasculogenesis. Since targeting on IGF for cancer therapy is rapidly becoming a clinical reality, a better understanding of IGFsmediated pathways has a relevant impact, providing new insights to help the design of newly developed drugs.

Keywords: BM-derived cells; Endothelial cells; Insulin; Insulin-like growth factors; Tumor angiogenesis

Document Type: Research Article

DOI: http://dx.doi.org/10.2174/092986709789352268

Affiliations: Dipartimento di Patologia Molecolare e Terapie Innovative, Universita Politecnica delle Marche, Via Tronto 10/A, 60020, Ancona, Italy.

Publication date: October 1, 2009

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  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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