New Therapeutic Targets for Drug Design Against Trypanosoma cruzi, Advances and Perspectives
We review six proteins involved in the biochemical metabolism of Trypanosoma cruzi that have recently been studied as potential targets for designing new drugs for Chagas disease. These are farnesyl pyrophosphate synthase, trans-sialidase, cruzain cystein protease, trypanothione reductase, glucose 6-phosphate-dehydrogenase, glyceraldehyde 3-phosphatedehydrogenase, and α-hydroxy acid dehydrogenase. We also review the advances of compounds recently designed based on structure-activity, and the perspectives of new compounds that inhibit these therapeutic targets.
Document Type: Research Article
Affiliations: Departamento de Biologia Molecular y Bioingenieria, Unidad Academica Multidisciplinaria Reynosa- Aztlan, Universidad Autonoma de Tamaulipas, Calle 16 y Lago de Chapala, s/n, Reynosa, Tamaulipas, 88740, Mexico.
Publication date: 2009-09-01
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