Combination of MafA, PDX-1 and NeuroD is a Useful Tool to Efficiently Induce Insulin-Producing Surrogate β -Cells

Authors: Kaneto, Hideaki; Matsuoka, Taka-aki; Katakami, Naoto; Matsuhisa, Munehide

Source: Current Medicinal Chemistry, Volume 16, Number 24, August 2009 , pp. 3144-3151(8)

Publisher: Bentham Science Publishers

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Abstract:

A decrease in the number of functioning pancreatic β-cells and insufficient insulin biosynthesis and/or secretion are the hallmarks of diabetes. Therefore, the identification of alternative sources to induce insulin-producing surrogate β-cells is of great importance. For the induction of insulin-producing cells from various cells and/or tissues, it is useful to mimic and reproduce expression alterations of various pancreatic transcription factors observed during normal pancreas development and to induce key pancreatic transcription factors which have the potency to induce insulin and other β-cell-related genes. MafA, PDX-1 and NeuroD directly bind to the insulin gene promoter and function as very important transcription factors in pancreatic β-cell differentiation and mature β-cell function. The combination of MafA, PDX-1 and NeuroD markedly induces insulin biosynthesis in various non-β-cells and thereby is a useful tool to efficiently induce insulin- producing surrogate β-cells.

Keywords: MafA; PDX-1; NeuroD; β-cell differentiation; surrogate β-cells

Document Type: Research article

DOI: http://dx.doi.org/10.2174/092986709788802980

Affiliations: 1: Department of Metabolic Medicine, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan.

Publication date: 2009-08-01

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Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.

Combination of MafA, PDX-1 and NeuroD is a Useful Tool to Efficiently Induce Insulin-Producing Surrogate β -Cells

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