Sulfated Oligosaccharides: New Targets for Drug Development?
Abstract:Sulfated oligosaccharides display an important role in biological processes. They bind proteins through interactions mediated by highly specific sequences (heparin - antithrombin, heparan sulfate - growth factors / herpes simplex virus) or by electrostatic interaction between sulfate groups and cationic sites of proteins. Sulfated oligosaccharides are involved in biological events as protein localisation at cell surfaces, the control of proteolysis, the modulation of the angiogenesis and metastasis of tumours, the oligomerisation of cell growth factors.
Sulfated residues have been recently found in glycoproteins, as GlcNAc or Mannose in N-glycosidic chains of different sources: gp120 of HIV, the envelope glycoprotein of influenza virus, the cysteine protease of Trypanosoma cruzi.
This paper reviews recent findings concerning the implication of sulfated sugars in carbohydrate - protein interactions, from glycosaminoglycans to glycosidic chains in proteins, and their potential application as new targets for drugs/vaccines/diagnosis developments will be discussed. New approaches for their detection and analysis (ESI-MS, MALDI, Molecular Imprinting) are presented.
Document Type: Research Article
Affiliations: Laboratoire des Glucides CNRS UMR 6219, Institut de Chimie de Picardie, Universite de Picardie Jules Verne, 33 Rue Saint-Leu, 80039 Amiens, France.
Publication date: 2009-06-01
More about this publication?
- Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.