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Pharmacological Implications of MMP-9 Inhibition by ACE Inhibitors

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Matrix metalloproteinase-9 (MMP-9) plays an important role in the onset and prognosis of myocardial infarction. Targets of angiotensin converting enzyme (ACE) inhibitors might include not only ACE but also MMP-9, and ACE seems to be closely associated with complications of hypertension such as cardiovascular remodeling whereas MMP-9 is closely related to coronary diseases. We postulate that ACE inhibitors prevent coronary diseases via direct MMP-9 inhibition and could interact with the MMP-9 active sites using specific modes similar to those used for the ACE active sites. Research of the molecular interaction between MMP-9 active sites and ACE inhibitors appears to be an important key in the development of effective MMP-9 inhibitors for cardiovascular protection.
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Keywords: Matrix metalloproteinase-9; angiotensin II receptor blocker; angiotensin converting enzyme inhibitor; cardiovascular protection; coronary diseases; inhibitory specificity; molecular interaction; myocardial infarction

Document Type: Research Article

Affiliations: Biomedical Computation Center, Osaka Medical College, 2-7 Daigakuchou, Takatuski, Osaka 569- 8686, Japan.

Publication date: 2009-04-01

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