Pharmacological Implications of MMP-9 Inhibition by ACE Inhibitors

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Abstract:

Matrix metalloproteinase-9 (MMP-9) plays an important role in the onset and prognosis of myocardial infarction. Targets of angiotensin converting enzyme (ACE) inhibitors might include not only ACE but also MMP-9, and ACE seems to be closely associated with complications of hypertension such as cardiovascular remodeling whereas MMP-9 is closely related to coronary diseases. We postulate that ACE inhibitors prevent coronary diseases via direct MMP-9 inhibition and could interact with the MMP-9 active sites using specific modes similar to those used for the ACE active sites. Research of the molecular interaction between MMP-9 active sites and ACE inhibitors appears to be an important key in the development of effective MMP-9 inhibitors for cardiovascular protection.

Keywords: Matrix metalloproteinase-9; angiotensin II receptor blocker; angiotensin converting enzyme inhibitor; cardiovascular protection; coronary diseases; inhibitory specificity; molecular interaction; myocardial infarction

Document Type: Research Article

DOI: http://dx.doi.org/10.2174/092986709787846514

Affiliations: Biomedical Computation Center, Osaka Medical College, 2-7 Daigakuchou, Takatuski, Osaka 569- 8686, Japan.

Publication date: April 1, 2009

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  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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