Stress-Activated MAP Kinase Cascades in Cellular Senescence

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Abstract:

In response to progressive telomere shortening in successive cell divisions, normal somatic cells withdraw from the cell cycle and exhibit irreversible growth arrest. This state, called cellular senescence, is induced not only by telomere shortening but also by various physico-chemical stressors that induce DNA damage and chromatin disruption as well as by strong mitogenic signals. Because senescent cells never re-enter the cell cycle, cellular senescence appears to prevent malignant transformation of damaged cells and thus contributes to tumor suppression. On the other hand, excess accumulation of senescent cells attenuates the integrity and normal function of tissues, leading to age-related diseases. In addition to the well-established roles of p53 and pRB in cellular senescence, recent evidence suggests that stress-activated mitogen- activated protein kinase (MAPK) cascades that converge on c-Jun N-terminal kinases (JNKs) and p38 MAPKs also play important roles in the regulation of cellular senescence. In this review, we focus on signaling that regulates stressinduced cellular senescence, with special focus on the JNK and p38 MAPK cascades.

Keywords: Cellular senescence; JNK; MAPK; p38; p53; pRB

Document Type: Research Article

DOI: http://dx.doi.org/10.2174/092986709787846613

Affiliations: Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3- 1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

Publication date: April 1, 2009

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  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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