Authors: Tziomalos, Konstantinos; Athyros, Vasilios G.; Karagiannis, Asterios; Mikhailidis, Dimitri P.

Source: Current Medicinal Chemistry, Volume 16, Number 6, February 2009 , pp. 676-684(9)

Publisher: Bentham Science Publishers

Abstract:

Inflammation plays an important role in the pathogenesis of atherosclerosis. Several cardiovascular drugs exert anti-inflammatory effects and accumulating data suggest that fibrates also share this property. This review summarizes the mechanisms implicated in the anti-inflammatory actions of fibrates. We also provide an overview of the existing clinical studies addressing the effects of fibrates on markers of inflammation. Several, but not all, studies reported that fibrates exert anti-inflammatory actions. The small number of patients included in some studies, as well as differences in diagnoses and duration of follow up might partly explain this discrepancy. It is also possible that fibrates differ substantially in terms of anti-inflammatory effects. It is not clear whether an anti-inflammatory action of fibrates is clinically relevant. Future studies should assess whether the anti-inflammatory actions of fibrates (or for that matter, other drugs) will translate into a reduced risk of vascular disease.

Keywords: Fibrates; C-reactive protein; interleukin; adhesion molecules; statins; inflammation

Document Type: Research article

DOI: http://dx.doi.org/10.2174/092986709787458416

Affiliations: 1: Academic Head, Department of Clinical Biochemistry, Royal Free Hospital Campus, University College Medical School, University College London, Pond Street, London NW3 2QG, UK.

Publication date: 2009-02-01

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• Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.

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