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The Anti Inflammatory Effects of High Density Lipoproteins

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Abstract:

It is well recognised that increased levels of high density lipoprotein (HDL) protect against atherosclerosis and correlate with improved prognosis for vascular disease associated events. While many of the atheroprotective effects of HDL are ascribed to the ability to remove cholesterol from the vasculature through the reverse cholesterol transport system, recent work has shown that HDL may be atheroprotective through its other functions, such as regulation of endothelial adhesion molecule expression, stimulation of endothelial nitric oxide synthase and inhibition of the damaging effects of oxidised low density lipoproteins. Recently, HDL has also been described to interact with circulating cells inhibiting both leukocyte and platelet activation, therefore having further systemic anti-inflammatory functions. This review summarises the studies and models used to examine the anti-inflammatory effects of HDL and details data describing the ability to inhibit leukocyte activation, contributing to the hypothesis that raised HDL is beneficial in the context of inflammation in atherosclerosis. Further, HDL modification in disease and current therapeutic strategies such as reconstituted HDL particles and apoA-I mimetic peptides is discussed to provide insights to the potential applicability of raising HDL to regress cardiovascular disease.

Keywords: HDL; adhesion; adhesion molecules; atherosclerosis; cardiovascular disease; inflammation; leukocytes; therapeutics

Document Type: Research Article

DOI: http://dx.doi.org/10.2174/092986709787458425

Affiliations: Baker IDI Heart and Diabetes Research Institute, PO Box 6492, St Kilda Road central, Melbourne, 8008, VIC, Australia.

Publication date: February 1, 2009

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  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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