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Polyethylenimine In Medicinal Chemistry

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Polyethylenimine (PEI), an organic branched or linear polyamine polymer, has been successfully used in the past for DNA complexation and transfection in vitro and in vivo into several cell lines and tissues. PEI was also applied in different fields from gene therapy and several studies have emphasized the importance of this polymer in medicinal chemistry. In this brief critical review the uses and applications of this versatile polymeric molecule will be discussed.

Keywords: DNA; Polyethylenimine; biomedical applications; drug delivery; gene therapy; medicinal chemistry; polymer; transfection

Document Type: Research Article


Affiliations: Chemistry Department, SAPIENZA University of Rome, P.le Aldo Moro 5, 00185 Rome - Italy.

Publication date: November 1, 2008

More about this publication?
  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.

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