Polyethylenimine In Medicinal Chemistry
Authors: Vicennati, Paola; Giuliano, Antonella; Ortaggi, Giancarlo; Masotti, Andrea
Source: Current Medicinal Chemistry, Volume 15, Number 27, November 2008 , pp. 2826-2839(14)
Publisher: Bentham Science Publishers
Abstract:Polyethylenimine (PEI), an organic branched or linear polyamine polymer, has been successfully used in the past for DNA complexation and transfection in vitro and in vivo into several cell lines and tissues. PEI was also applied in different fields from gene therapy and several studies have emphasized the importance of this polymer in medicinal chemistry. In this brief critical review the uses and applications of this versatile polymeric molecule will be discussed.
Document Type: Research Article
Affiliations: Chemistry Department, SAPIENZA University of Rome, P.le Aldo Moro 5, 00185 Rome - Italy.
Publication date: November 1, 2008
- Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.