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Platelet-Monocyte Interactions - A Dangerous Liaison Linking Thrombosis, Inflammation and Atherosclerosis

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Atherosclerosis is an inflammatory disease. Monocyte-platelet interactions may play a key role in this process by various pathways. They “inflame” each other as well as adjacent cell types at the vascular wall by direct physical interactions, autocrine and paracrine activation processes. These processes promote monocyte recruitment (in)to the vascular wall - a key mechanism in atherogenesis. This article highlights the molecular basis and the inflammatory pathways initiated by platelet-monocyte interactions.

Keywords: Atherosclerosis; Cytokine; Monocyte-platelet interactions; Receptor; Thrombosis; inflammatory disease

Document Type: Research Article

DOI: http://dx.doi.org/10.2174/092986708785132852

Affiliations: Medizinische Klinik III, Universitatsklinikum Tubingen, Otfried-Muller Str.10, 72076 Tubingen, Germany.

Publication date: August 1, 2008

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  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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