Advances in Parallel Screening of Drug Candidates
Abstract:In the hit to lead process, a drug candidate is selected from a set of potential leads by screening its binding with potential targets. This review focuses on the lead identification assays that employ a bio-chemical or bio-physical test to detect molecular recognition events between proteins and small molecules in a parallel format.These tests require either the lead or the target immobilization followed by incubation with the set of potential interaction partners and detection of a signal related to the target-ligand binding. In the first part of the review the different detection strategies amenable for drug screening are discussed. In the second part, a review of immobilization approaches for leads or targets, allowing the parallel screening of arrays of molecules, is presented.
Document Type: Research Article
Affiliations: Istituto di Chimica del Riconoscimento Molecolare (ICRM), C.N.R., Via Mario Bianco, 9 20131, Milano,Italy.
Publication date: July 1, 2008
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