Authors: Moreno, Juan A.; Sanchez-Nino, Maria D.o.l.o.r.e.s.; Sanz, Ana B.e.l.e.n.; Lassila, Markus; Holthofer, Harry; Blanco-Colio, Luis M.i.g.u.e.l.; Egido, Jesus; Ruiz-Ortega, Marta; Ortiz, Alberto

Source: Current Medicinal Chemistry, Volume 15, Number 16, July 2008 , pp. 1645-1654(10)

Publisher: Bentham Science Publishers

Abstract:

Recent advances have identified the podocyte as a key target in glomerular injury. The podocyte is a highly specialized cell which is responsible for the glomerular permselectivity for proteins in the kidney. Podocyte injury or loss leads to proteinuria. Apoptosis has been shown to contribute to renal cell loss, including loss of podocytes. The most striking feature of the podocyte is its ability to form intricate specialized cell junctions, the slit diaphragm. Slit diaphragm proteins play an important role in podocyte biology, protein permselectivity, cell signalling and disease. This review focuses on recent advances on the understanding of podocyte survival regulation, its relationship to slit diaphragm structure and function, and how this knowledge may affect our therapeutic approach to proteinuric kidney disease.

Keywords: Apoptosis; glomerular injury; nephrotic syndrome; podocyte; proteinuria; slit diaphragm; renal disease

Document Type: Research article

DOI: http://dx.doi.org/10.2174/092986708784911542

Affiliations: 1: Renal and Vascular Research Laboratory,Fundacion Jimenez Diaz, Avda Reyes Catolicos 2, 28040 Madrid, Espana.

Publication date: 2008-07-01

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• Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.

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• By this author: Moreno, Juan A. ;  Sanchez-Nino, Maria D.o.l.o.r.e.s. ;  Sanz, Ana B.e.l.e.n. ;  Lassila, Markus ;  Holthofer, Harry ;  Blanco-Colio, Luis M.i.g.u.e.l. ;  Egido, Jesus ;  Ruiz-Ortega, Marta ;  Ortiz, Alberto

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