Procarbazine - A Traditional Drug in the Treatment of Malignant Gliomas

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Abstract:

The methylhydrazine derivative Procarbazine (PCZ) as monotherapy or in combination with CCNU and vincristine (PCV) was evaluated in a vast number of clinical trials and is still used in patients with high-grade and low-grade gliomas. The compound is an antineoplastic agent with multiple sites of action. It inhibits incorporation of small DNA precursors, as well as RNA and protein synthesis. PCZ can also directly damage DNA through an alkylation reaction. The drug is not cross-resistant with other mustard-type alkylating agents. As PCZ was in almost all trials used in a combination with CCNU and Vincristin, the efficacy can only be evaluated in the view of the PCV regimen. The published data suggest a role of PCV as a salvage regimen, especially in oligodendroglial tumors; however, well designed studies with high evidence are rare in all entities. This article summarizes the existing data with the goal to define the role of PCZ/PCV in modern neurooncology.

Keywords: PCV; Procarbazine; anaplastic glioma; chemotherapy; clinical trial; glioblastoma; glioma; pharmacokinetics

Document Type: Research Article

DOI: http://dx.doi.org/10.2174/092986708784567707

Affiliations: Division of NeuroOncology, Klinik und Poliklinik fur Neurologie der Universitat Regensburg am Bezirksklinikum, Universitatsstra├če 84, 93053 Regensburg, Germany.

Publication date: June 1, 2008

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  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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