Skip to main content

Why Chemokines are Cytokines while their Receptors are not Cytokine Ones?

Buy Article:

$63.00 plus tax (Refund Policy)


Chemotactic cytokines, or chemokines, are a large family of small proteins, which are distinguished from other cytokines in that they are the only members of the cytokine family that act on G-protein coupled receptor superfamily. This minireview tries to answer the title question by structure/function analysis of chemokines, cytokines, and their receptors. We also consider secretion of chemokines/ cytokines in health and disease as well as expression of their receptors both in immune system and brain. Our analysis suggests that cytokine and chemokine receptors may share similar architecture with Toll-like receptors. Such similarity hints a similar way of their functioning as molecular switches controlled by protein-protein interactions. Hence, we pay attention to the related receptor-receptor associations and evolutionary conserved leucine-rich motifs.

Keywords: Leucine-rich motif; Toll-like receptor; protein-protein interaction

Document Type: Research Article


Affiliations: 14-line 39, St. Petersburg, 199178, Russia.

Publication date: June 1, 2008

More about this publication?
  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.

Access Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more