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Free Content Epigenetic Treatment of Myelodysplastic Syndromes and Acute Myeloid Leukemias

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Abstract:

Epigenetic mechanisms affecting chromatin structure contribute to regulate gene expression and assure the inheritance of information, which are essential for the proper expression of key regulatory genes in healthy cells, tissues and organs. In the medical field, an increasing body of evidence indicates that altered gene expression or de-regulated gene function lead to disease. Cancer cells also suffer a profound change in the genomic methylation patterns and chromatin status. Aberrant DNA methylation patterns, changes in chromatin structure and in gene expression are common in all kind of tumor types. However, studies on leukemias have provided paradigmatic examples for the functional implications of the epigenetic alterations in cancer development and progression as well as their relevance for therapeutical targeting.

Keywords: AML; HDAC inhibitors; MDS; epigenetics; hypomethylating agents

Document Type: Research Article

DOI: http://dx.doi.org/10.2174/092986708784534947

Affiliations: Istituto di Ematologia, Universita Cattolica S. Cuore, L.go A. Gemelli, 1, 00168 ROMA, Italy.

Publication date: June 1, 2008

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  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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