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Targeted Therapies in the Treatment of Renal Cell Carcinoma

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Abstract:

The management of renal cell carcinoma (RCC) has undergone rapid and radical evolution over the last few years. An improved understanding of the underlying biology of RCC has led to the approval of several new therapies directed against specific and relevant biological targets, so-called “targeted therapies.” These highly effective treatments are now entering routine use, however many questions still remain as to how best to use these agents and integrate them into the broader therapeutic armamentarium. This review summarizes the major published clinical trials of the new agents, discusses the controversies and research questions that have arisen as a result, and considers some of the issues that remain.

Keywords: Renal cell carcinoma; angiogenesis; kidney cancer; kinase inhibitors; signal transduction inhibitors; stroma; vasculature

Document Type: Research Article

DOI: http://dx.doi.org/10.2174/092986708784310440

Affiliations: Joint Ludwig-Austin Medical Oncology Unit, Austin Hospital, Studley Rd, Heidelberg, Victoria 3084, Australia.

Publication date: May 1, 2008

More about this publication?
  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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