Aminobisphosphonates as New Weapons for γ δ T Cell-Based Immunotherapy of Cancer
Authors: Caccamo, Nadia; Meraviglia, Serena; Cicero, Giuseppe; Gulotta, Gaspare; Moschella, Francesco; Cordova, Adriana; Gulotta, Eliana; Salerno, Alfredo; Dieli, Francesco
Source: Current Medicinal Chemistry, Volume 15, Number 12, May 2008 , pp. 1147-1153(7)
Publisher: Bentham Science Publishers
Abstract:Several observations in mice and in humans have collectively laid the foundation for examining the potential of γ δ T cells to exert tumor immunotherapy. Human γ δ T cells can be activated in a non-MHC dependent fashion either by low molecular mass phosphoantigens, or by agents that provoke the accumulation of endogenous pyrophosphates such as isopentenylpyrophosphate. Among the latter, aminobisphosphonates are well-established in the clinic, and extensive data are available on the compounds' antiangiogenic, antiosteolytic and pro-apoptotic properties. In this review we discuss on the possibility that the intentional activation of γ δ T cells in vivo by aminobisphosphonates may represent a promising target for the design of novel and highly innovative immunotherapy in patients with different types of cancer.
Document Type: Research Article
Affiliations: Dipartimento di Biopatologia e Metodologie Biomediche, Universita di Palermo, Corso Tukory 211,Palermo 90134 Italy.
Publication date: May 1, 2008
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