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Aminobisphosphonates as New Weapons for γ δ T Cell-Based Immunotherapy of Cancer

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Several observations in mice and in humans have collectively laid the foundation for examining the potential of γ δ T cells to exert tumor immunotherapy. Human γ δ T cells can be activated in a non-MHC dependent fashion either by low molecular mass phosphoantigens, or by agents that provoke the accumulation of endogenous pyrophosphates such as isopentenylpyrophosphate. Among the latter, aminobisphosphonates are well-established in the clinic, and extensive data are available on the compounds' antiangiogenic, antiosteolytic and pro-apoptotic properties. In this review we discuss on the possibility that the intentional activation of γ δ T cells in vivo by aminobisphosphonates may represent a promising target for the design of novel and highly innovative immunotherapy in patients with different types of cancer.

Keywords: Human γ δ T cells; bisphosphonates; immunotherapy; phosphoantigens; tumors

Document Type: Research Article


Affiliations: Dipartimento di Biopatologia e Metodologie Biomediche, Universita di Palermo, Corso Tukory 211,Palermo 90134 Italy.

Publication date: 2008-05-01

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