Expression, Regulation and Function of Asporin, A Susceptibility Gene in Common Bone and Joint Diseases

$63.00 plus tax (Refund Policy)

Buy Article:

Abstract:

Asporin is an extracellular matrix protein that belongs to the small leucine-rich repeat proteoglycan (SLRP) family of proteins. It is unique among SLRPs in that it lacks a glycosaminoglycan attachment site and contains an asparatic acid (D) repeat at its amino terminus. Its biological role has been unclear, but recent genetic studies have demonstrated association between asporin and various bone and joint diseases, including osteoarthritis, rheumatoid arthritis and lumbar disc disease. Each of these common diseases presents a substantial medical, social and economical burden to societies worldwide. This paper reviews recent progress in the study of asporin, focusing on its expression, regulation and function as well as its role in the molecular pathogenesis of common bone and joint diseases. Asporin is found primarily in regions surrounding skeletal tissue and is up-regulated in disease states. It binds to various growth factors, including TGF-β and BMP-2, and negatively regulates their activity. By inhibiting binding of TGF-β1 to its type II receptor, asporin forms a functional feedback loop with TGF-β1 and regulates its chondrogenic potential. As an extracellular, tissue-specific protein, asporin represents a promising target for phamacogenomic approaches to common bone and joint diseases.

Keywords: Asporin; D-repeat; SLRP; TGF-β; association; bone and joint diseases; osteoarthritis

Document Type: Research Article

DOI: http://dx.doi.org/10.2174/092986708783885237

Affiliations: Laboratory for Bone and Joint Diseases,SNP Research Center, RIKEN, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639,Japan.

Publication date: March 1, 2008

More about this publication?
  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
Related content

Tools

Favourites

Share Content

Access Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content
Cookie Policy
X
Cookie Policy
ingentaconnect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more