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Polyelectrolyte Multilayer Films: From Physico-Chemical Properties to the Control of Cellular Processes

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Polyelectrolyte multilayer films have been well characterized for almost two decades and there is now a growing interest for the development of biomimetic films that could be used in vitro or in vivo to control cellular behaviors. In this review, the important properties of multilayer films designed for cell/surface interactions will be highlighted. The first part will deal with the physico-chemical properties of polypeptide and polysaccharide multilayer films, including their growth, swellability, stability and mechanical properties. In the second part, we will focus on important properties influencing cellular behaviors: i) film biodegradability, ii) film mechanical properties, iii) film bioactivity achieved by either the intrinsic properties of the film components or the insertion of small peptides, proteins, or DNA. In particular, films thicker than one micron are particularly well suited for loading bioactive molecules due to their reservoir capacities.

Keywords: Layer-by-layer; adhesion; bioactivity; biodegradability; biopolymers; cellular processes; drug release; polysaccharides

Document Type: Research Article

DOI: http://dx.doi.org/10.2174/092986708783885219

Affiliations: DIMNP, UMR 5235, Dynamique des Interactions Membranaires Normales et Pathologiques, CNRS, Universite Montpellier II et I, cc 107, 34 095 Montpellier Cedex 05, France.

Publication date: March 1, 2008

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  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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