Proteomics and Cardiovascular Disease: An Update

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Abstract:

Proteomics has unraveled important questions in the biology of cardiovascular disease and holds even greater promise for the development of novel diagnostic and prognostic biomarkers. This approach may establish early detection strategies, and monitor responses to therapies. Technological advances (most notably blue native polyacrylamide gel electrophoresis, electrospray ionization, matrix- assisted laser desorption/ionization (MALDI), analysis of MALDI-derived peptides in Time-of-Flight (TOF) analyzers, and multidimensional protein identification technology (MudPIT) and bioinformatics for data handling and interpretation allow a large-scale identification of peptide sequence and post-translational modifications. Moreover, combination of proteomic biomarkers with clinical phenotype, metabolite changes, and genetic haplotype information is promising for the physician assessment of individual cardiovascular risk profile.

Keywords: Proteomics; cardiovascular disease; mass spectrometry; two-dimensional gel electrophoresis

Document Type: Research Article

DOI: http://dx.doi.org/10.2174/092986708783769713

Affiliations: Department of General Pathology, Division of Clinical Pathology and Excellence Research Center on Cardiovascular Diseases,Complesso S. Andrea delle Dame, 1st School of Medicine, II University of Naples, 80138 Naples, Italy.

Publication date: March 1, 2008

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  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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