Provider: Ingenta Connect
Database: Ingenta Connect
Content: application/x-research-info-systems
TY - ABST
AU - Cheng, Xian-Chao
AU - Wang, Qiang
AU - Fang, Hao
AU - Xu, Wen-Fang
TI - Role of Sulfonamide Group in Matrix Metalloproteinase Inhibitors
JO - Current Medicinal Chemistry
PY - 2008-02-01T00:00:00///
VL - 15
IS - 4
SP - 368
EP - 373
KW - Matrix metalloproteinases
KW - hydrogen bond
KW - sulfonamide
KW - gauche conformation
KW - inhibitors
KW - zinc binding group
N2 - Sulfonamide hydroxamates were designed and synthesized as efficient matrix metalloproteinase (MMP) inhibitors since the discovery of CGS 27023A in 1994. The sulfonamide group was incorporated in the inhibitor to improve the enzyme-inhibitor binding, not only by forming hydrogen bonds to the enzyme but also by properly directing the hydrophobic substituent to the S1' pocket and enabling it to plunge in deeply. Some researchers even presumed that the sulfonamide group, together with the zinc binding group (ZBG), coordinated the zinc ion within the MMP active site. This review will illustrate the role of the sulfonamide group in MMP inhibitors.
UR - https://www.ingentaconnect.com/content/ben/cmc/2008/00000015/00000004/art00005
M3 - doi:10.2174/092986708783497300
UR - https://doi.org/10.2174/092986708783497300
ER -