Current and Emerging Therapeutic Approaches in HCV-Related Mixed Cryoglobulinemia
Authors: Sansonno, D.; Tucci, F. A.; Troiani, L.; Sansonno, L.; Dammacco, F.
Source: Current Medicinal Chemistry, Volume 15, Number 2, January 2008 , pp. 117-126(10)
Publisher: Bentham Science Publishers
Abstract:Recognition of hepatitis C virus (HCV) as an etiological factor in mixed cryoglobulinemia (MC) has dramatically changed our point of view in its treatment. Emphasis is placed on abatement and clearance of viral load and deletion of clonal expansions of IgM molecules with rheumatoid factor activity-synthesising B cells. The purpose of this review is to discuss the underlying scientific rationale and results of clinical studies of new treatment approaches to MC, with a focus on cell-depleting therapies and chemokine blockade. Additional antiviral agents directed to several phases of HCV life cycle acting with different or alternate mechanisms are proposed with the goal to enhance response rates more broadly suitable for MC patients with vasculitis and peripheral neuropathies. The majority of the available data on these new treatment approaches stems from open-label studies, but controlled trials are under way. Therapy directed against chemokines and/or cytokines represents an interesting and promising future target.
Document Type: Research Article
Affiliations: Department of Biomedical Sciences and Human Oncology, Section of Internal Medicine and Clinical Oncology, University of Bari Medical School, Policlinico, Piazza Giulio Cesare 11, 70124 BARI - Italy.
Publication date: January 2008
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