Modified Influenza Virosomes: Recent Advances and Potential in Gene Delivery

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Abstract:

Influenza virosomes have proven to be effective vehicles for the delivery of antigens in the vaccination of humans against a number of pathogens. However, their potential as a means for gene delivery has yet to be realized. Chemical modification of viruses is emerging as a new strategy for production of safe and efficient gene delivery systems. Influenza virosomes exhibit many of the features of the virus, such as for cell binding, uptake and endosomal escape, which can be easily engineered into designer delivery vehicles capable of safe, efficient and cell-specific cargo delivery. This review focuses on the next generation of influenza virosomes and highlights aspects of their modification that may lead to simple but effective gene delivery vehicles.

Keywords: Influenza virosomes; endocytosis; envelope proteins; gene delivery; pH-sensitive bonds; polyethylene glycol (PEG)

Document Type: Research Article

DOI: http://dx.doi.org/10.2174/092986707782793989

Affiliations: School of Biomedical Sciences, University of Queensland, Brisbane, Qld 4072, Australia.

Publication date: December 1, 2007

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  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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