The Molecular Basis of Susceptibility to Infection in Liver Cirrhosis

Authors: Chavez-Tapia, Norberto C.; Torre-Delgadillo, Aldo; Tellez-Avila, Felix I.; Uribe, Misael

Source: Current Medicinal Chemistry, Volume 14, Number 28, December 2007 , pp. 2954-2958(5)

Publisher: Bentham Science Publishers

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Abstract:

There is much clinical evidence of a relationship between infectious disease and chronic liver disease. The consequences of this adverse association have been described and advances in the treatment and prophylaxis of infectious disease have had an important effect on the management of patients with chronic liver disease. The association between infectious disease and chronic liver disease involves altered cytokine production, cellular immunity, and vascular response. However, there is little information on the mechanisms underlying these phenomena. In this report, we review the mechanistic basis of this common association.

Keywords: Infections; cirrhosis; cytokine; vascular; susceptibility

Document Type: Research article

DOI: http://dx.doi.org/10.2174/092986707782794041

Affiliations: 1: Departamento de Gastroenterologia.Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran. Vasco de Quiroga #5. Col. Seccion XVI. Del. Tlalpan. C.P. 14000, Distrito Federal, Mexico.

Publication date: 2007-12-01

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Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.