Recent Progress in Rational Drug Design of Neuraminidase Inhibitors

Authors: Liu, Yu; Zhang, Jie; Xu, Wenfang

Source: Current Medicinal Chemistry, Volume 14, Number 27, November 2007 , pp. 2872-2891(20)

Publisher: Bentham Science Publishers

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Abstract:

Neuraminidase is a major glycoprotein of influenza virus which is essential for viral infection and offers a potential target for antiviral drug development. Rational drug design of NA inhibitors is now in the clinic and these molecules are effective and safe for the treatment of influenza. Recently, research of structure-based NA inhibitors is becoming an interesting field, leading to a breakthrough in the control of influenza. Here we review the progress in the rational drug design of NA inhibitors in recent years.

Keywords: Influenza virus; neuraminidase; neuraminidase inhibitor; pharmacophore model; antiviral agent

Document Type: Research article

Affiliations: 1: Department of Medicinal Chemistry,School of Pharmaceutical Sciences, ShanDong University, 44, West Wenhua Road,250012, Ji'nan, ShanDong, P.R.China.

Publication date: 2007-11-01

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Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.