Therapeutic Targets in Respiratory Viral Infections

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Abstract:

Respiratory viral infections account for a substantial proportion of morbidity world wide and contribute notably to the socioeconomic burden of diseases. Amongst the most important viruses identified so far are Rhinoviruses, Influenza A and Respiratory Syncytial Virus. The knowledge base has broadened at the clinical and experimental level in recent years. However, therapeutic options are still limited. This may be partly due to the multiplicity of infectious mechanisms and the complex underlying host/virus interactions. The aim of this article is to give an overview of the different respiratory viruses involved, their major principles of infection and the associated therapeutic targets and to review up-to-date virus-specific clinical trials.

Keywords: Treatment; airway; antiviral; influenza; respiratory; rhinovirus; rsv; virus

Document Type: Research Article

DOI: http://dx.doi.org/10.2174/092986707782360132

Affiliations: University Hospital Bergmannsheil,Medical Clinic III, Department of Pneumology, Allergology and Sleep Medicine, D-44789 Bochum, Germany.

Publication date: November 1, 2007

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  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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