Authors: Jesse Dawson,; Terry Quinn,; Matthew Walters,

Source: Current Medicinal Chemistry, Volume 14, Number 17, July 2007 , pp. 1879-1886(8)

Publisher: Bentham Science Publishers

Abstract:

Uric acid is the end-product of purine catabolism. Hyperuricaemia is implicated in disorders such as gout and urolithiasis and recent epidemiological evidence suggests an association between increasing uric acid levels and increased cardiovascular morbidity and mortality. A direct causal role remains to be established but recent studies of losartan, atorvastatin and fenofibrate suggest that uric acid reduction contributes to attenuation of cardiovascular risk. Furthermore, several small studies of xanthine oxidase inhibition (the most common method of uric acid reduction) have shown improvements in measures of cardiovascular and endothelial function of a similar magnitude to those of other proven preventative strategies.

This review introduces the epidemiological data, discusses strategies to lower uric acid and outlines the available clinical trial data supporting uric acid reduction as a potential and novel method of reducing the burden of cardiovascular disease.

Keywords: Uric acid; xanthine oxidase; cardiovascular disease; prevention

Document Type: Research article

DOI: http://dx.doi.org/10.2174/092986707781058797

Affiliations: 1: Division of Cardiovascular and Medical Sciences, University of Glasgow, Western Infirmary Hospital, Dumbarton Road, Glasgow, G11 6NT, UK.

Publication date: 2007-07-01

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• Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.

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