@article {Claudio:2007:0929-8673:1829,
title = "Molecular Hybridization: A Useful Tool in the Design of New Drug Prototypes",
journal = "Current Medicinal Chemistry",
parent_itemid = "infobike://ben/cmc",
publishercode ="ben",
year = "2007",
volume = "14",
number = "17",
publication date ="2007-07-01T00:00:00",
pages = "1829-1852",
itemtype = "ARTICLE",
issn = "0929-8673",
url = "https://www.ingentaconnect.com/content/ben/cmc/2007/00000014/00000017/art00003",
doi = "doi:10.2174/092986707781058805",
keyword = "Molecular hybridization, Pharmacophoric group combination, Hybrid compounds, Drug design",
author = "Claudio Viegas-Junior and Amanda Danuello and Vanderlan da Silva Bolzani and Eliezer J. Barreiro and Carlos Alberto Manssour Fraga",
abstract = "Molecular hybridization is a new concept in drug design and development based on the combination of pharmacophoric moieties of different bioactive substances to produce a new hybrid compound with improved affinity and efficacy, when compared to the parent drugs. Additionally, this strategy can result in compounds presenting modified selectivity profile, different and/or dual modes of action and reduced undesired side effects. So, in this paper, we described several examples of different strategies for drug design, discovery and pharmacomodulation focused on new innovative hybrid compounds presenting analgesic, anti-inflammatory, platelet anti-aggregating, anti-infectious, anticancer, cardio- and neuroactive properties.",
}