Abstract:In our review entitled “Radioligand Development for PET Imaging of -Amyloid (Aβ) ” Current Status” by Cai, et al. in Current Medicinal Chemistry, 2007, 14 , 19-52.
Please note brain uptake values at 2, 30, and 60 min in Table 23 are not uniformly in %SUV [(%ID/g) x g (body weight)] as implied. For example, the data shown are [(%ID/g) x kg (body weight)] for PIB in mouse and %ID/g for IMPY also in mouse. Because the average mouse weighs about 30 g (0.03 kg), the value for IMPY would need to be corrected by a factor of about 0.03 to be directly comparable with that of PIB. A compound with a brain uptake of 0.21 %ID/g at 2 min would not be the same as PIB. In fact, that compound would be about 30-fold inferior to PIB with regard to brain uptake and would likely fail as an in vivo imaging agent.
The numbers are taken directly from the original references. Due to lack of animal body weight data and the different species from which data had been obtained, strictly comparable SUV values could not be calculated. However, these differences were mistakenly not noted in the Table. Interested readers should consult the original references for details. The ratios of radioactivity between 2 and 30 min, or 2 and 60 min, as listed in the Table remain correct. We apologize for this error and the inconvenience to the reader.
Document Type: Research Article
Affiliations: Molecular Imaging Branch National Institute of Mental Health National Institutes of Health Bethesda, MD 20892 USA.
Publication date: June 1, 2007
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