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Diseases Originating from Altered Protein Quality Control in the Endoplasmic Reticulum

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Abstract:

A challenging question in biology is how cells control their shape and volume. The relative abundance of organelles can be radically modified to comply with a new task, an example being the massive development of the endoplasmic reticulum (ER) in Ig-secreting plasma cells. The ER is the site where secretory proteins are made and folded. Remarkably, it can discriminate between native and non-native proteins, restricting transport to the former, whilst retaining and eventually degrading the latter (quality control). Recent studies revealed that certain components of the unfolded protein response (UPR), a multidimensional signalling pathway originally discovered in cells exposed to severe ER stress, are crucial for the normal development of secretory cells. According to the cell types, different arms of the UPR are required: the IRE1-XBP1 pathway is essential for plasma cell differentiation, whilst the PERK-eIF2α pathway is essential for pancreatic β cells survival. Therefore, the UPR is far from being a monolithic response. Disturbances in the signalling pathways that allow the ER to satisfy the changing demand of protein synthesis can occur at various levels and often cause diseases. Here we summarize the molecular mechanisms underlying this variegated and constantly growing class of pathological conditions, focusing on diseases that are linked to alterations in the quality control functions that the ER exerts over its protein products.





Keywords: ER proliferation; ER storage disease; ERAD; Endoplasmic reticulum; UPR; aggregation; quality control; transport

Document Type: Research Article

DOI: http://dx.doi.org/10.2174/092986707780830952

Affiliations: Universita Vita Salute San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milano, Italy.

Publication date: June 1, 2007

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  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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