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Tumor Necrosis Factor-Alpha Monoclonal Antibodies for Crohn's Disease: Tipping the Balance

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Abstract:

Crohn's disease (CD) is a chronic inflammatory disorder which may involve any part of gastrointestinal tract. Chronic inflammation is primarily due to an immunological imbalance between pro- and anti-inflammatory cytokines, and with a defective apoptosis of lamina propria T cells. Amongst the pro-inflammatory cytokines tumor necrosis factor-α (TNF-α) seems to play a central role in pathogenesis of CD.

Over the last years, increasing knowledge on the pathogenesis of CD together with progresses in bio-technology have led to the development of a number of biological agents targeting specific molecules involved in gut inflammation, most importantly TNF-α and its receptors.

The aim of this paper is to critically review the rationale and state-of-the art for the use TNF-α inhibitors in the treatment of CD.

Keywords: Certolizumab pegol; Infliximab; Lipopolysaccaride; T lymphocytes; TNF receptors; Toll-like receptors

Document Type: Research Article

DOI: https://doi.org/10.2174/092986707780831104

Affiliations: Division of Gastroenterology,Istituto Clinico Humanitas-IRCCS in Gastroenterology, Viale Manzoni, Rozzano,Milan, Italy.

Publication date: 2007-06-01

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