Dual Action-Based Approaches to Antibacterial Agents

Authors: Bremner, John B.; Ambrus, Joseph I.; Samosorn, Siritron

Source: Current Medicinal Chemistry, Volume 14, Number 13, June 2007 , pp. 1459-1477(19)

Publisher: Bentham Science Publishers

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Abstract:

This review collates and analyses recent work done on dual action approaches to tackling the mounting health problem of resistance by human pathogenic bacteria to antibacterial agents. In particular the areas reviewed include the use of two drugs in combination, dual action prodrugs, and dual action drugs (or hybrid drugs)

Keywords: Dual action antibacterials; bacterial resistance; dual action drugs; dual action prodrugs

Document Type: Research article

DOI: http://dx.doi.org/10.2174/092986707780831168

Affiliations: 1: Department of Chemistry,University of Wollongong, Wollongong, NSW, 2522, Australia.

Publication date: 2007-06-01

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Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.