A Review on Synthetic and Natural Steroid Dimers: 1997-2006

Authors: Nahar, L.; Sarker, S. D.; Turner, A. B.

Source: Current Medicinal Chemistry, Volume 14, Number 12, May 2007 , pp. 1349-1370(22)

Publisher: Bentham Science Publishers

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Abstract:

Since the publication of the review by Li and Dias in 1997, which covered almost all steroid dimers known to us until the early part of 1997, there have been significant amounts of work carried out on steroid dimers, and another review on this topic has long been overdue. Thus, this review presents a comprehensive review of literature published over the last decade on various aspects of steroid dimers, including synthesis and applications. Steroid dimers that were published before 1997 but were not covered within the previous review have also been included.

Keywords: Steroids dimer; synthesis; molecular umbrella; anticancer; cephalostatins; ritterazines; crellastatins; natural product

Document Type: Research article

DOI: http://dx.doi.org/10.2174/092986707780597880

Affiliations: 1: School of Biomedical Sciences, University of Ulster at Coleraine, Cromore Road, Coleraine BT52 1SA, Co. Londonderry,Northern Ireland, UK.

Publication date: 2007-05-01

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Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.