Combined Biomarkers for Early Alzheimer Disease Diagnosis

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Abstract:

Few public health problems have captured the attention of the biomedical and lay communities alike as has Alzheimer Disease (AD). Several questions remain still open in disease management, as the necessity to delineate disease process from “normal ageing”. In the last few years, Mild Cognitive Impairment (MCI) has received significant attention, thus it represents the major risk factor for AD. Not all people diagnosed as having MCI, however, will develop AD, hence there is a need to reliably predict progression.

To this aim, different biomarkers have been proposed with the attempt to identify MCI people who already have pre-clinical AD. Neuropsychological assessment, peripheral and CSF biomarkers as well as neuroimaging findings (both structural and functional) have reported variable accuracy values, but better results have been obtained by combined biomarker approach.

In this review, we summarise the most recent findings on combined biomarkers and their usefulness in clinical practice for the early and preclinical diagnosis of AD.

Keywords: Alzheimer disease; amyloid precursor protein; biomarkers; cerebrospinal fluid; mild cognitive impairment; platelets; proteomics

Document Type: Research Article

DOI: http://dx.doi.org/10.2174/092986707780598005

Affiliations: Clinica Neurologica, Universita degli Studi di Brescia, Pza Spedali Civili, 1 - 25100 Brescia, Italy.

Publication date: May 1, 2007

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  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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