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New Insights into Aminoglycoside Antibiotics and Derivatives

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Abstract:

In the post-genome era, RNA has emerged as a valid molecular target involved in many biochemical pathways such as cellular protein interactions. This includes transcription and translation, HIV-Rev and HIV-tat proteins binding to HIV RNA that encode HIV genetic information. The binding of natural and synthetic aminoglycosides to RNA or RNA-protein complexes has been a central focus of small molecules-RNA recognition events, since they bind selectively to a variety of RNA targets. The understanding of the contribution of shape-based and charge motifs involved in aminoglycosides-RNA complexes gives remarkable information of the translational miscoding process, thereby opening new insights for drug discovery. This review comprises relevant information about aminoglycosides antibiotics, including chemical structure, molecular mechanism, structureactivity relationships, recent advances in aminoglycoside mimetics over the last four years, resistance mechanisms and structuretoxicity relationships.

Keywords: Aminoglycoside antibiotics; aminoglycoside mimetics; structure-activity relationships

Document Type: Research Article

DOI: https://doi.org/10.2174/092986707780362817

Affiliations: Department of Pharmaceutical Sciences, Phaculty of Pharmaceutical Sciences, University of São Paulo, CEP 14040-903, Ribeirão Preto, Brazil.

Publication date: 2007-04-01

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  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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