Genomic and Proteomic Screening of Apoptosis Mitochondrial Regulators for Drug Target Discovery

Authors: Lecellier, Gael; Brenner, Catherine

Source: Current Medicinal Chemistry, Volume 14, Number 8, April 2007 , pp. 875-881(7)

Publisher: Bentham Science Publishers

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Abstract:

Screening strategies of therapeutic molecules and targets have received increasing attention during the past few years. Indeed, identification of novel compounds and drug targets involved in apoptosis control is a major rate-limiting step in anticancer drug development efforts. In this review, we discuss the current screening methodologies to discover novel potential therapeutics targets and drugs implicated in the apoptotic pathway, in particular the intrinsic pathway. In addition, we present a proteomic screening strategy that led us to identify a mitochondrial glutathione-S-transferase as a novel regulator of the pro-apoptotic adenine nucleotide translocase pore function.

Keywords: Cell death; Mitochondria; Permeability transition pore; Glutathione S-transferase

Document Type: Research article

DOI: http://dx.doi.org/10.2174/092986707780363005

Affiliations: 1: CNRS UMR8159,Universite de Versailles/SQY, 45, avenue des Etats-Unis, 78035 Versailles, France.

Publication date: 2007-04-01

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Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.