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Immunologic Aspects of Sublingual Immunotherapy in the Treatment of Allergy and Asthma

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Abstract:

Recently interest has been focused on the administration of allergen specific immunotherapy by the oral route particularly sublingually. The mechanism by which sublingual immunotherapy exerts its effects remain unclear. Most likely, allergen captured within the oral mucosa by Langerhan's-like dendritic cells play a role in subsequent T cell responses. There is a growing body of evidence to support the role of regulatory T cells in controlling the development of allergic diseases. Nevertheless, there remains a lack of firm evidence that sublingual immunotherapy induces regulatory T cells. New vaccine developments with the increasing understanding of the molecular engineering techniques are on the way to offer the opportunity to design recombinant allergens that are safe, effective and easy to administer. In addition, the idea of using adjuvants along with allergen within the oral cavity is another promising approach.

Keywords: Adjuvant; allergy; asthma; oral dendritic cell; recombinant vaccine; sublingual immunotherapy

Document Type: Research Article

DOI: http://dx.doi.org/10.2174/092986707779941168

Affiliations: Division of Pediatric Allergy and Immunology, School of Medicine, Marmara University Hospital, 5. Gazeteciler Sitesi, C-5 Blok D 42, Akatlar, 34335, Istanbul, Turkey.

Publication date: February 1, 2007

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  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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