Phosphonated nucleosides represent a promising alternative in the improvement of the biological activity of nucleoside analogues in antiviral and anticancer chemotherapy. The basic concept, the chemistry, the different structural modifications and their effects on the antiviral potency will be discussed in this review.
Dipartimento Farmaco-Chimico, Universita degli Studi di Messina, Viale S.S. Annunziata, 98168 Messina, Italy.
Publication date: December 1, 2006
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