Synthesis and Biological Activity of Phosphonated Nucleosides: Part 1Furanose, Carbocyclic and Heterocyclic Analogues
Abstract:Phosphonated nucleosides represent a promising alternative in the improvement of the biological activity of nucleoside analogues in antiviral and anticancer chemotherapy. The basic concept, the chemistry, the different structural modifications and their effects on the antiviral potency will be discussed in this review.
Document Type: Research Article
Affiliations: Dipartimento Farmaco-Chimico, Universita degli Studi di Messina, Viale S.S. Annunziata, 98168 Messina, Italy.
Publication date: December 1, 2006
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