Synthesis and Biological Activity of Phosphonated Nucleosides: Part 1Furanose, Carbocyclic and Heterocyclic Analogues

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Abstract:

Phosphonated nucleosides represent a promising alternative in the improvement of the biological activity of nucleoside analogues in antiviral and anticancer chemotherapy. The basic concept, the chemistry, the different structural modifications and their effects on the antiviral potency will be discussed in this review.

Keywords: Nucleotides; anti-HIV; anti-herpes; antiviral; nucleic acids; nucleosides; phosphonates

Document Type: Research Article

DOI: http://dx.doi.org/10.2174/092986706779026110

Affiliations: Dipartimento Farmaco-Chimico, Universita degli Studi di Messina, Viale S.S. Annunziata, 98168 Messina, Italy.

Publication date: December 1, 2006

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  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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