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Effects of Progesterone on Sleep: A Possible Pharmacological Treatment for Sleep-Breathing Disorders?

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Abstract:

Progesterone is present in a wide spectrum of biological activity within a variety of tissues. This hormone is also known to affect reproduction, sleep quality, respiration, mood, appetite, learning, memory and sexual activity. Progesterone exerts a sleep induction or hypnotic effect and is a potent respiratory stimulant that has been associated to a decrease in the number of central and obstructive sleep apnea episodes in men. The literature also contains a substantial amount of data on the effect of apnea in women with obesityhypoventilation during menopause. This review attempts to outline the specific role of progesterone in normal sleep and breathing as well as its possible therapeutic effects in the treatment of sleep-disordered breathing.

Keywords: Progesterone; breathing; hormonal control; sleep; sleep apnea

Document Type: Research Article

DOI: http://dx.doi.org/10.2174/092986706779026200

Affiliations: Department of Psychobiology - Universidade Federal de Sao Paulo, Rua Napoleao de Barros, 925, Vila Clementino - SP- 04024-002, Sao Paulo, Brazil.

Publication date: December 1, 2006

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  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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